中年和老年人肌肉强度与痴呆症之间的关联:全国纵向研究
Wei Jin1, Sheng Liu1, Li Huang2
1Department of Vascular Surgery, the First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Journal of psychiatric research
|October 1, 2025
概括
低肌肉强度,包括握手和下肢强度,在中年和老年人中显著增加痴呆风险. 保持肌肉力量对于预防和评估痴呆症至关重要.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 全球人口老龄化正在推动痴呆病例的增加.
- 痴呆症是一个重大的公共卫生挑战,特别是在老年人中.
- 了解可修改的风险因素对于痴呆症预防策略至关重要.
研究的目的:
- 调查肌肉强度与痴呆风险之间的关联.
- 为了检查上肢和下肢肌肉力量对痴呆发病率的影响.
- 为基于肌肉力量的痴呆症预防干预提供证据.
主要方法:
- 利用了来自50岁以上的5916名英国成年人的数据,这些数据来自英国长度老龄化研究 (ELSA).
- 通过手握强度 (HGS),标准化HGS和椅子上升时间来评估肌肉力量.
- 采用考克斯比例危险模型来分析肌肉强度三角形和痴呆风险之间的关系,平均随访时间为9.2年.
主要成果:
- 共有197名参与者 (3.33%) 患有痴呆症.
- 低握力 (HR=2.84) 和标准化的握力 (HR=2.20的BMI标准化,HR=1.74的体重标准化) 与明显更高的痴呆风险有关.
- 长时间起床时间 (HR=2.75),表明下肢力量较弱,也与痴呆风险增加相关.
- 关联在各个年龄和性别子组以及敏感性分析中保持一致.
结论:
- 肌肉力量,包括上肢 (HGS) 和下肢 (椅上升) 功能,是痴呆症发展的重要预测因素.
- 保持或改善肌肉力量可能在预防和延迟痴呆症发病方面发挥关键作用.
- 这些发现支持将肌肉力量评估纳入痴呆风险评估,并突出了干预策略的潜在目标.
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