患有原发性头痛的成年人有抑郁和自杀的风险
Back Kim1, Sangwoo Park2, Su Kyoung Lee3
1Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea; College of Medicine, Seoul National University, Seoul, Republic of Korea.
Journal of psychiatric research
|October 1, 2025
概括
主要头痛,如紧张型头痛和偏头痛显著增加男性和女性的抑郁风险. 紧张型头痛也会增加男性的自杀风险,这凸显了综合心理健康护理的必要性.
科学领域:
- 神经学和精神病学 精神病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 主要头痛,包括紧张型头痛 (TTH) 和偏头痛,是普遍存在的疾病.
- 这些头痛与抑郁症和自杀等并发症有关,但时间关系不清楚.
- 以前的研究经常使用自我报告的数据或横截面设计,限制因果推理.
研究的目的:
- 调查一次性头痛与随后的抑郁和自杀风险之间的时间关联.
- 为了区分与紧张型头痛和偏头痛相关的风险.
- 在一个大规模的,基于人口的队列中检查这些协会.
主要方法:
- 一项回顾性队列研究,利用来自国家健康保险服务-国家健康查队列 (459,347名参与者) 的数据.
- 暴露时间: 2002-2005 年的主要头痛 (TTH,偏头痛).
- 结果:从2006年到2019年的抑郁和自杀,使用考克斯比例危险回归模型进行分析.
主要成果:
- 主要头痛与两性抑郁症风险增加有显著的相关性 (TTH aHR=1.55;偏头痛 aHR=1.50).
- 紧张型头痛在男性 (aHR=1.39) 中与更高的自杀风险有统计学显著的关联,但在女性 (aHR=1.11) 中没有.
- 偏头痛与自杀风险增加没有显著关联 (aHR=1.16).
结论:
- 初级头痛与男性和女性患抑郁症的风险更高有关.
- 紧张型头痛与男性自杀风险增加特别相关.
- 头痛疾病的综合管理必须解决身体和心理健康方面的问题,特别是在男性中.
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