解读基本元素对精子质量和精子蛋白质完整性的影响 - 一个体外和体内研究
Parameswari R1, Jesu Jaya Sudan R2, Lesitha Jeeva Kumari J2
1Department of Biotechnology, Thiruvalluvar University, Serkkadu, Vellore, Tamil Nadu 632115, India.
概括
,,和等基本元素对精子健康至关重要. 患有三精子症的男性的较低水平与精子形态,DNA完整性和运动性差异相关,影响男性生育能力.
科学领域:
- 生殖生物学 生殖生物学
- 生物化学 生物化学
- 计算生物学 计算生物学
背景情况:
- 基本元素 (EEs) 对于精子发生,保持精子形态和运动性至关重要.
- 像,,和这样的EEs是精子功能和完整性的重要营养素和辅助因子.
研究的目的:
- 调查基本元素与精子形态,质量和完整性之间的关系.
- 探索精子蛋白,特别是精子凝素在调解这些关系中的作用.
- 进行体外和体内分析,以了解元素-蛋白相互作用.
主要方法:
- 在normozoospermic和teratozoospermic个体中对基本元素度的比较分析 (n=116).
- 使用计算机辅助精液分析 (CASA),原子吸收光谱,ELISA,MDA分析,SCSA和AO染色的精液分析.
- 在基林上预测离子结合点.
主要成果:
- 与常态动物种子受试者相比,,,和的度显著降低.
- 这些EEs的水平降低与精子形态变化,DNA碎片化增加和运动性降低相关.
- 在分析中证实了Zn,Mg和Se的特定金属结合基因在semenogelin中,在normozoospermic和teratozoospermic群体之间存在差异.
结论:
- 适当水平的基本元素,特别是,,和,对于保持正常的精子形态和完整性至关重要.
- 在semenogelin中发现的金属结合基因强调了这些元素在支持强大的精子功能中的作用.
- 这些发现强调了EEs在男性生殖健康中的重要性,并建议临床干预的潜在目标.
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