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相关概念视频

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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相关实验视频

Updated: Jan 16, 2026

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
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跨脑脉冲刺激调节神经元活动和功能网络动态.

Maria Eleni Karakatsani1, Irmak Gezginer1, Daniil Nozdriukhin1

  • 1Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093, Zurich, Switzerland.

Brain stimulation
|October 1, 2025
PubMed
概括

超脉冲刺激 (TPS) 通过诱导流入和重组神经网络来调节大脑活动. 这种非侵入性技术显示出治疗诸如阿尔茨海默氏症之类的神经系统疾病的潜力.

关键词:
的流入的流入.功能网络的重组功能网络的重组.治疗性超声波治疗性超声波通过皮脉冲刺激.

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Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
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Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
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相关实验视频

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科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 生物医学工程 生物医学工程

背景情况:

  • 跨脉动刺激 (TPS) 是一种新的非侵入性脑刺激技术.
  • 它对包括阿尔茨海默病 (AD) 在内的神经系统疾病的治疗潜力正在调查中.
  • 导致TPS对大脑活动的影响的确切机制在很大程度上是未知的.

研究的目的:

  • 研究TPS对神经元活动和大脑电路的影响.
  • 为了比较健康和AD小鼠模型中的TPS效应.

主要方法:

  • 在GCaMP+小鼠中利用光素成像.
  • 与静止状态功能磁共振成像 (rs-fMRI) 结合使用.
  • 使用c-Fos免疫组织化学用于神经元激活的验证结果.

主要成果:

  • TPS诱导了显著的流入,并增加了牙状环中的c-Fos表达.
  • 观察到功能连接的快速,短暂的重组,特别是在边缘区域.
  • 较高的TPS强度触发了扩散的去极化波.

结论:

  • 在没有有害的热效应的情况下,TPS机械效应调节大脑活动.
  • 研究结果阐明了TPS机制,支持其在神经退行性疾病治疗中的应用.
  • 表明TPS可以被优化为神经系统疾病的治疗策略.