核化红细胞作为性重症患者死亡率的预后标记:一项观察性研究
Felix Niebhagen1, Anna Kirsch1, Richard Schau1
1Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, TU Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
Anaesthesia, critical care & pain medicine
|October 1, 2025
概括
核化红细胞 (NRBCs) 可以预测严重病情的败血症患者的死亡率. 最大NRBC计数≥100/μL显著增加了在ICU死亡的风险.
科学领域:
- 临界护理医学 临界护理医学
- 血液学 血液学 血液学
- 败血症研究 败血症研究
背景情况:
- 核化红细胞 (NRBC) 与重症患者的死亡率更高有关.
- 在败血症中NRBCs的预后价值特别需要进一步澄清.
研究的目的:
- 评估NRBCs对败血症患者死亡率的预测有效性.
主要方法:
- 在2020-2023年期间收集了465名感染性重症患者的数据.
- 分析了每日NRBC值,并确定了死亡率的预测有效性.
- 使用ROC分析和Youden的方法来确定在ICU停留期间最大NRBC的死亡率截止水平.
主要成果:
- 死亡的患者的NRBC最大值 (290/μL) 比幸存者 (30/μL) 高得多.
- 最大NRBC切断值≥100/μL的患者发现,他们的ICU死亡率明显更高 (AUC为0.745).
- 升高的NRBC (≥100/μL) 与五倍增加的死亡几率 (OR 5.03) 和更高的死亡率 (HR 1.84) 相关.
结论:
- NRBC测量提供了高预后准确性,用于预测性重症患者的死亡率.
- 一个NRBC值≥100/μL有效地分层这种患者群的死亡风险.
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