在真菌菌菌病和塞萨里综合征的种族差异:一个多中心队列研究研究
Pamela B Allen1, Subir Goyal2, Swaminathan Iyer3
1Department of Hematology, Winship Cancer Institute, Atlanta, Georgia.
Journal of the American Academy of Dermatology
|October 1, 2025
概括
黑人患有真菌菌菌病和塞萨里综合征 (MF/SS) 的患者具有更高风险的特征和更差的生存率,特别是在老年人中. 需要进一步的研究来了解MF/SS结果中的这些差异.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 种族与真菌菌菌病和塞萨里综合征 (MF/SS) 的结果之间的关联仍然不清楚.
- 了解MF/SS的种族差异对于公平的患者护理至关重要.
研究的目的:
- 调查自我认同的种族对MF/SS的临床特征和患者结果的影响.
- 为了评估MF/SS.诊断的黑人和白人患者之间的生存差异.
主要方法:
- 来自7所学术机构的883名MF/SS患者的回顾性队列分析 (2010-2021年).
- 纳入标准:确认MF/SS诊断,一致的随访,以及可用的病理学报告.
- 统计分析包括单变量/多变量模型和卡普兰-梅尔总生存率,重点关注黑人患者的结果.
主要成果:
- 该队列包括419名 (47.4%) 黑人和464名 (56.6%) 白人患者.
- 与白人患者相比,黑人患者在诊断时更年轻,并呈现出更高的疾病阶段.
- 60岁以上的黑人患者的整体存活率比他们的白人同行更差.
结论:
- 患有MF/SS的黑人患者表现出更具侵略性的临床特征和降低的生存率,特别是在老年人群中.
- 局限性包括来自学术中心的潜在推偏见和缺乏中央病理学审查,需要谨慎解释.
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