慢性支气管炎在COPD中的定义对10年所有原因死亡率的预测进行比较
Joon Young Choi1, Hyoung Kyu Yoon2, Youlim Kim3
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
使用COPD评估测试 (CAT-CB) 的慢性支气管炎 (CB) 的新定义比经典定义更好地预测COPD患者的10年死亡率. 严重的CAT-CB表明死亡风险更高.
科学领域:
- 肺部医学 肺部医学
- 临床流行病学临床流行病学
- 呼吸系统健康 呼吸系统健康
背景情况:
- 慢性支气管炎 (CB) 是慢性阻塞性肺病 (COPD) 的显著表型,与不良健康结果有关.
- 准确识别CB表型对于预测患者预后至关重要.
研究的目的:
- 基于COPD评估测试 (CAT-CB) 的CB定义的预测性能与COPD患者10年全因死亡率的经典定义进行比较.
- 为了评估CAT-CB定义的不同层的预后值.
主要方法:
- 来自前性多中心韩国COPD小组研究 (KOCOSS) 的3476名参与者的分析.
- 使用经典ATS定义和CAT-CB定义 (基于咳和的CAT项目) 进行CB的分类.
- 考克斯的比例危险模型被用来评估10年所有原因的死亡风险.
主要成果:
- 根据CAT-CB的定义,发现的患者比传统的定义 (11.0%) 更多 (22.6%).
- CAT-CB独立地与所有原因死亡率的增加有关,而经典定义并非如此.
- 只有在严重的CAT-CB小组中观察到显著的死亡风险;轻度的CAT-CB没有显示过度风险.
结论:
- 与经典定义相比,基于CAT的CB定义在识别长期死亡风险较高的COPD患者方面表现优越.
- 特定的CAT症状得分 (咳和) 单独预测死亡率,与经典定义组件不同.
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