过去和现在口服避孕药的使用与恐惧调节之间的关联
Lisa-Marie Davignon1, Alexandra Brouillard1, Sean Devine2
1Research Center of the Institut Universitaire en Santé Mentale de Montréal, Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal, Montreal, Quebec, Canada; Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|October 1, 2025
概括
口服避孕药 (OC) 使用会损害恐惧灭绝回忆,与大脑活动变化有关. 过去的OC使用也可能影响恐惧调节,特别是在低雌激素 (E2) 状态期间.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 内分泌学 在内分泌学.
背景情况:
- 低内源性雌激素 (E2) 与受损的恐惧灭绝记忆回忆有关.
- 荷尔蒙避孕药 (口服避孕药,OC) 可能会产生长期的心理影响.
- 对OC使用对灭绝记忆的长期影响还没有得到充分的研究.
研究的目的:
- 复制关于OC使用和改变灭绝回忆的发现.
- 调查OC使用与灭绝记忆的潜在长期关联.
- 检查OC使用和灭绝回忆的神经相关性.
主要方法:
- 对147名健康成年人进行了恐惧协议 (调节,灭绝学习,灭绝回忆,恐惧更新).
- 检查了心理生理学 (皮肤导电性反应,SCRs) 和神经差异.
- 根据雌激素 (E2) 水平和口服避孕药 (OC) 史分组参与者.
主要成果:
- 与排卵前妇女和从未使用者相比,目前的OC使用者在灭绝回忆期间显示出更高的SCR.
- 在OC使用者中,在灭绝期间的SCR回忆与海马,ACC和vmPFC激活相关.
- 过去的OC用户在早期的卵泡阶段表现出类似于当前OC用户的SCRs.
结论:
- 目前的OC使用与恐惧灭绝回忆受损有关.
- 神经相关物包括腹中前额叶皮质 (vmPFC),前带皮质 (ACC) 和海马.
- 过去的OC使用可能对恐惧调节有持久的影响,特别是在低E2状态下.
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