关于GRAPPA的辩论:是否确定临床内炎指数不反映真实内炎,因此应该停止使用?
Betul Macit1, Sibel Z Aydin2, Atul Deodhar3
1B. Macit, MD, Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA; betul_macit@brown.edu.
The Journal of rheumatology
|October 1, 2025
概括
关于在牛皮病 (PsD) 中评估肠炎的辩论质疑传统的临床指数. 专家们支持或反对停止治疗,理由是限制和需要更好的炎症检测方法.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 肠炎是牛皮病 (PsD) 的一个关键特征.
- 目前对肠炎的评估工具存在局限性,包括区分炎症和非炎症原因以及高安慰剂反应.
- 牛皮和牛皮关节炎研究和评估小组 (GRAPPA) 2024年会议主办了一场关于停止传统临床肠炎指数的辩论.
研究的目的:
- 关于在牛皮病中继续使用传统的临床肠炎指数进行辩论.
- 分析停止这些指数的支持和反对的论点.
- 讨论对未来临床实践中肠炎评估的影响.
主要方法:
- 在GRAPPA 2024年度会议上使用辩论格式.
- 论点由Sibel Aydin博士 (支持停药) 和Atul Deodhar博士 (反对停药) 提出.
- 讨论了关于临床指数的局限性和替代成像模式的挑战的证据.
主要成果:
- 艾丁博士认为,临床指数往往衡量"肠道炎症",而不是真正的炎症性肠道炎症,缺乏特异性.
- 德奥达尔博士反驳说,传统指数促进了成功的临床试验和治疗牛皮关节炎的药物批准.
- 新兴成像工具的挑战,如超声波,包括操作员的依赖性和缺乏标准化的监管批准.
结论:
- 在牛皮病中评估肠炎的最佳方法仍在讨论中.
- 需要平衡既有临床指数的实用性与新型成像技术的潜力.
- 需要进一步的研究和验证才能在PsD中进行可靠和特定的肠炎评估.
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