睡眠不良与大脑老龄化有关:系统性炎症的作用
Yuyang Miao1, Jiao Wang2, Xuerui Li3
1Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China; Department of Medicine (Huddinge), Karolinska Institutet, Stockholm, Sweden.
EBioMedicine
|October 1, 2025
概括
睡眠模式不佳与加速的大脑衰老有关,这可能是由系统性炎症增加所驱动的. 保持健康的睡眠可能会保护大脑健康.
科学领域:
- 神经科学是一个神经科学.
- 睡眠科学 睡眠科学
- 老年学是一门学科.
背景情况:
- 睡眠质量差是增加痴呆风险的已知危险因素.
- 研究健康睡眠模式与大脑衰老之间的联系对于理解神经退行性疾病至关重要.
- 系统性炎症是睡眠与大脑健康之间关系的潜在调解者.
研究的目的:
- 为了检查健康睡眠模式和大脑年龄在一个大成年人群中之间的关联.
- 为了确定系统性炎症是否介导睡眠模式和大脑年龄差异之间的关系.
- 为了解睡眠对大脑衰老的影响背后的机制提供见解.
主要方法:
- 利用英国生物银行对27,500名成年人的数据,评估睡眠特征,以定义健康,中等和不良的睡眠模式.
- 使用INFLA-score测量了低级系统性炎症,这是炎症生物标志物的综合指数.
- 估计大脑年龄差距 (BAG) 使用机器学习模型对大脑MRI数据进行估计,平均随访时间为8.9年.
主要成果:
- 与健康睡眠相比,不良睡眠模式 (中等和不良) 与大脑年龄差距 (BAG) 的较高显著相关.
- INFLA评分部分介导了中等睡眠和睡眠不足与BAG增加之间的关联,分别解释了6.81%和10.42%.
- 很大一部分参与者在基线时表现出中等 (55.6%) 或差 (3.3%) 的睡眠模式.
结论:
- 睡眠不良可能导致大脑加速衰老.
- 升高的全身炎症似乎是驱动睡眠不足对大脑衰老的负面影响的关键机制.
- 促进健康的睡眠习惯可能是保持大脑健康和降低痴呆风险的潜在策略.
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