相关实验视频

Updated: Jan 16, 2026

LERLIC-MS/MS for In-depth Characterization and Quantification of Glutamine and Asparagine Deamidation in Shotgun Proteomics
08:01

LERLIC-MS/MS for In-depth Characterization and Quantification of Glutamine and Asparagine Deamidation in Shotgun Proteomics

Published on: April 9, 2017

8.5K

[阿斯巴拉金除的分析及其对γS-晶体聚合物的影响]

Koichi Kato1

  • 1Faculty of Pharmaceutical Sciences, Shonan University of Medical Scinences.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
|October 1, 2025
PubMed
概括

非酶性蛋白质除化,特别是透镜晶体中的阿斯巴拉金 (Asn),有助于白内障. 特定的脊柱形状加快了Asn脱amidation,影响了蛋白质的稳定性和聚合,为与年龄相关的疾病提供了洞察力.

关键词:
结晶晶晶晶晶晶晶晶晶晶晶脱阿米迪化脱阿米迪化分子动力学模拟模拟蛋白质聚合蛋白质的聚合物量子化学计算的量子化学计算

更多相关视频

Experimental Approaches for Biochemical Analysis of Glial Fibrillary Acidic Protein and Its Disease-associated Variants06:02

Experimental Approaches for Biochemical Analysis of Glial Fibrillary Acidic Protein and Its Disease-associated Variants

Published on: November 28, 2025

384
Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast11:04

Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast

Published on: June 23, 2018

7.6K

相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
11.6K