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Updated: Jan 16, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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[开发针对癌症相关激酶的中型双对应抑制剂]

Kohei Tsuji1

  • 1Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU) (Currently known as Laboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo).

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
|October 1, 2025
PubMed
概括

研究人员开发了新的双价抑制剂,通过将PBD结合与激酶域抑制剂结合起来,准波罗样激酶1 (Plk1). 这些化合物表现出增强的Plk1亲和力和对癌细胞显著的细胞毒性.

关键词:
这是一种双价值的方法.这是一种激酶抑制剂.类酸是一种酸.波罗盒子域名 (PBD) 是一个波罗盒子域.波罗样类激酶1 (Plk1) 的存在.

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