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Updated: Jan 16, 2026

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关于LGR4,R-spondin和ZNRF3对Wnt/β-catenin信号调节的结构性见解

Yuxuan Peng1, Akiko Fujimura1, Jinta Asami1

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

Nature communications
|October 1, 2025
PubMed
概括

结构洞察力揭示了蛋白丰富的重复含有G蛋白结合受体4 (LGR4) 和R-蛋白2 (RSPO2) 复合体与和环指3 (ZNRF3) 如何调节Wnt/β-catenin信号传递,这对发育和癌症至关重要.

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