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Updated: Jan 16, 2026

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基于Hsp90-Tau相互作用的合成护卫剂抑制了Tau的聚合,并挽救了生理上的Tau-Microtubule相互作用

Davide Di Lorenzo1,2,3, Nicolo Bisi1,4, Julia Kaffy1

  • 1Université Paris-Saclay, CNRS, BioCIS, Bat. Henri Moissan, 17 av. des Sciences, 91400, Orsay, France.

Nature communications
|October 1, 2025
PubMed
概括

一种新型的,β-Hsp90,模仿伴侣Hsp90,以抑制阿尔茨海默病 (AD) 模型中的Tau聚合. 这种可以恢复微管的功能,还可以减少粉样β聚合,从而提供双重治疗方法.

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