描述密集收集的纵向顺序数据的可变性,使用隐性线条模型
Mark Lunt1, David A Selby2, William G Dixon1,3
1Centre for Epidemiology Versus Arthritis, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Scientific reports
|October 1, 2025
概括
本研究引入了新的统计指标,即从中位数平均绝对偏差 (MADM) 和从预期平均绝对偏差 (MADE),用于分析通过移动设备收集的患者报告的症状数据,改进了纵向健康研究的见解.
科学领域:
- 生物统计学 生物统计学
- 数字健康数字健康
- 人口健康 人口健康
背景情况:
- 来自移动设备的纵向患者报告的症状数据提供了独特的见解,但也带来了分析挑战.
- 顺序尺度,不规则的抽样和时间自相关性使这些数据的分析复杂化.
研究的目的:
- 引入新的总结措施,用于分析人口健康研究中的顺序结果.
- 为纵向患者报告的结果数据提供可解释和计算高效的工具.
主要方法:
- 介绍从中位数 (MADM) 中的平均绝对偏差,用于横截面分析.
- 从预期中平均绝对偏差 (MADE) 的发展,使用潜伏累积模型,对纵向数据进行处罚线条.
- 潜伏累积模型解释了平凡性,并允许在不规则的时间点之间顺利过渡.
主要成果:
- 模拟表明,当违反正常性或静止性假设时,拟议的措施优于标准方法.
- 应用到"有机会疼痛的阴云"研究表明在特征症状变化和趋势的有用性.
- MADE 方法是可解释的,高效的,并且在标准的统计软件中很容易实现.
结论:
- 开发的MADM和MADE措施提供了直观的工具来分析纵向研究中患者报告的结果.
- 这些方法增强了移动健康数据的分析,解决了普通和不规则采样的挑战.
- 潜在的应用包括预测建模,因果发现和干预评估在人口健康研究.
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