在山东省的Helicobacter pylori抗菌耐药性和基因变异
Zhijing Xue1,2, Qi Zhao3, Fengyan Pei4
1Department of Gastroenterology, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250013, Shandong, China. 573799518@qq.com.
Scientific reports
|October 1, 2025
概括
在中国山东地区,Helicobacter pylori的抗生素耐药性很高,对阿齐思罗米辛,克拉里思罗米辛,莱沃素,莫西素和美特罗尼达的耐药性有很高的比例. 持续监测对于有效的治疗策略至关重要.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 杆菌 (H. pylori) 的抗生素耐药性显著降低了根除成功率.
- 关于H. pylori抗生素耐药性流行率和中国山东的遗传机制的数据有限.
研究的目的:
- 评估H. pylori对常见抗生素的抗生素耐药性的流行率和分子机制. 在山东.
- 为该地区提供有效的H. pylori根除疗法提供信息.
主要方法:
- 对8种抗生素进行抗微生物敏感性测试 (E测试).
- 抗性相关基因的PCR放大.
- 32种H. pylori菌株的全基因组测序.
主要成果:
- 对阿齐思罗米辛 (56.45%),克拉里思罗米辛 (33.87%),勒沃素 (48.39%),莫西素 (56.45%) 和美特罗尼达 (43.55%) 观察到高耐药率.
- 双重,三重和四重阻力是普遍存在的.
- 23S rRNA 和 gyrA 基因中的特定突变与对分别宏化物和诺基诺的耐药性相关.
- 截断的rdxA基因与美特罗尼达耐药性相关.
结论:
- 山东的H. pylori表现出抗生素耐药性和多种药物耐药性的高率.
- 对宏化物,基诺和甲尼达产生抗性的分子机制已被确定.
- 对H. pylori抗生素耐药性的持续监测对于山东人群至关重要.
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