严重的延迟凝血病由塞福拉/苏尔巴克坦引起:一个病例报告
Siqin Sun1, Yixuan Wang2, Jie Min1
1Department of Pharmacy, West China Hospital, Sichuan University, China.
The Journal of international medical research
|October 1, 2025
概括
塞福拉/苏尔巴克坦可以通过抑制维生素K循环引起严重的凝血病. 及时的维生素K1治疗显著改善了细菌性肺炎患者的凝血,突出了危险人群需要警监测的必要性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
- 血液学 血液学 血液学
背景情况:
- 严重的凝血病是与使用抗生素相关的潜在不良反应.
- 塞福拉/苏尔巴克坦是一种用于细菌感染的抗生素组合.
- 维生素K对于凝血因子的合成至关重要.
研究的目的:
- 报告严重凝血病的病例,怀疑是塞福拉/苏尔巴克坦引起的.
- 研究涉及维生素K循环抑制的潜在机制.
- 为了强调在治疗中监测凝血参数的重要性,塞福拉/苏尔巴克坦.
主要方法:
- 一个病例报告,一个患有细菌性肺炎的患者接受了用Cefoperazone/sulbactam治疗.
- 在23天内静脉注射塞福拉/苏尔巴克坦 (1.5g每8小时).
- 凝血参数的监测 (前血时间,激活的部分血栓形成时间,国际正常化比率) 和使用纳兰霍尺度进行评估.
主要成果:
- 患者在治疗的第26天出现了延长的凝血时间.
- 在服用维生素K1后,凝血参数显著改善 (PT -88.4%,aPTT -61.1%,INR -88.5%).
- 纳兰乔评分为5的评分表明凝血病与赛福拉/苏巴克坦之间可能存在关联.
结论:
- 塞福拉/苏尔巴克坦可以通过抑制维生素K循环诱导凝血病,导致缺乏.
- 维生素K1治疗可以有效地逆转这种抗生素诱导的凝血病.
- 在接受塞福拉/苏尔巴克坦治疗的患者中,对凝血病的延长监测至关重要,特别是那些高危出血的患者.
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