睡眠时间,抑郁和认知衰退轨迹之间的关联:来自中国前性队列研究的发现
Chenyu Li1, Xiaomin Wu1, Yu Li1
1Department of Epidemiology & Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
BMC psychiatry
|October 1, 2025
概括
较短的睡眠时间,定义为每晚6小时或更少,与45岁以上的中国成年人更快的认知衰退有关. 抑郁症症状似乎没有影响这种关系.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 认知能力下降是全球人口老龄化的一个重大问题.
- 了解睡眠等可修改的风险因素对于开发干预措施至关重要.
- 以前的研究表明,睡眠与认知健康之间存在联系,但需要在不同人群中进行更多的研究.
研究的目的:
- 研究45岁及以上中国成年人睡眠时间 (总睡眠时间,夜间睡眠时间和午睡时间) 与认知能力下降轨迹之间的关联.
- 检查基线抑郁症状在睡眠时间和认知能力下降之间的关系中的潜在调解作用.
主要方法:
- 利用了来自中国健康与退休长度研究 (CHARLS) 的数据,这是一项全国性调查.
- 分类总睡眠,夜间睡眠和白天小睡的持续时间.
- 采用基于群体的轨迹建模 (GBTM) 来识别不同的认知衰退模式.
- 使用多项逻辑回归来分析关联,包括抑郁症作为调解器.
主要成果:
- 确定了三个认知轨迹组:高水平稳定,中等水平缓慢衰退和低水平快速衰退.
- 与稳定的认知相比,较短的总睡眠时间 (≤6小时) 与缓慢和快速的认知衰退轨迹有关.
- 较短的夜间睡眠时间 (≤6小时) 也显示出与缓慢和快速认知衰退轨迹的显著关联.
- 基线抑郁症状没有调解睡眠时间和认知能力下降之间的观察到的关系.
结论:
- 较短的总和夜间睡眠时间与中国老年人的不良认知衰退轨迹有显著的关联.
- 这些发现强调了充分睡眠对于维持老年人群的认知功能的重要性.
- 在这个群体中,抑郁症似乎不是睡眠时间和认知衰退之间的联系的调解因素.
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