益生菌减轻了由莱特醇诱导的PCOS的卵巢血管干扰
Stephanie E Areloegbe1, Ikenna A Abugu1, Isaac O Ajadi2
1Cardio/Endo-metabolic and Microbiome Research Unit, Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, P.M.B. 5454, Ado-Ekiti, 360101, Nigeria.
BMC complementary medicine and therapies
|October 2, 2025
概括
益生菌改善了多囊性卵巢综合征 (PCOS) 鼠标模型中的卵巢功能,通过减少异常的卵巢血管生成. 这种治疗调节了Mfn2并抑制了HDAC2,为PCOS相关的不孕症提供了潜在的治疗益处.
科学领域:
- 生殖内分泌学和新陈代谢
- 微生物组和肠道健康
- 血管生物学和血管生成
背景情况:
- 多囊性卵巢综合征 (PCOS) 是导致女性不孕的主要原因,与代谢障碍和卵巢功能障碍有关.
- 血管内皮生长因子 (VEGF) 在内皮功能障碍和卵巢问题中起作用.
- 益生菌,有益的肠道微生物,可能通过表观遗传机制影响代谢健康.
研究的目的:
- 调查益生菌在改善异常卵巢血管生成中的治疗潜力,在PCOS大鼠模型中.
- 探索益生菌对卵巢功能和PCOS相关代谢和血管原生标记物的影响.
主要方法:
- 多囊性卵巢综合征 (PCOS) 在雌性Wistar大鼠中被诱导使用莱特.
- 随后,大鼠用益生菌 (3 × 10^9 CFU) 治疗了六周.
- 评估了卵巢形态,代谢压力标志物,血管生成因子,抗氧化防御和表观遗传调节剂.
主要成果:
- 莱特醇诱导的PCOS大鼠表现出肥胖,高雄性,卵巢囊,VEGF升高和基因组脱乙酶2 (HDAC2) 的增加.
- 患有PCOS的老鼠表现出卵巢炎症,脂质过氧化,抗氧化防御 (NrF2) 和线粒素2 (Mfn2) 的减少.
- 益生菌治疗显著逆转了这些PCOS相关的病理变化,改善了卵巢功能.
结论:
- 益生菌有效地改善异常卵巢血管生成,并改善PCOS大鼠模型中的卵巢功能.
- 益生菌的有益作用包括调节线粒素2 (Mfn2) 和抑制基因素脱乙酶2 (HDAC2).
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