早期的甲状腺切除术导致内脏脂肪组织炎症和葡萄糖不耐受
David J Buckley1, Sogol Zahedi1, Prema Velusamy1
1Department of Kinesiology, University of Texas Arlington, Arlington, TX, USA.
Immunity & ageing : I & A
|October 2, 2025
概括
早期的乳腺切除加速T细胞的衰老,导致肝脏和脂肪组织的炎症,葡萄糖不耐受性和年轻小鼠的脆弱性. 这种T细胞功能障碍会影响新陈代谢健康和免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢健康 代谢健康
- 衰老研究研究 衰老研究
背景情况:
- 脂肪组织和肝脏中的T细胞有助于老年小鼠的葡萄糖不耐受.
- 早期的乳腺切除术在年轻,健康的小鼠中诱导T细胞衰老表型.
研究的目的:
- 调查小鼠早期的甲状腺切除是否会导致T细胞过早衰老,导致年轻小鼠的炎症和葡萄糖不耐受.
主要方法:
- 小鼠在三周大时接受了乳腺切除术.
- 对9个月大的小鼠进行了表型和分子分析 (包括大量RNAseq).
- 进行了组织病理学和代谢评估.
主要成果:
- 甲状腺切除术的小鼠表现出葡萄糖不耐受,脆弱性增加,以及在脏,肝脏和周围脂肪组织 (pgWAT) 中的T细胞种群 (较少的天真,更多的记忆细胞) 发生变化.
- pgWAT分析揭示了上调的免疫激活和炎症基因以及下调的代谢功能基因.
- 在pgWAT中的T细胞显示出化学因受体表达和炎症标记的增加,独立于脂肪组织扩张.
结论:
- 幼年时的乳腺切除术诱导pgWAT的T细胞介导炎症,系统性葡萄糖不耐受,成年小鼠的脆弱性.
- 过早的T细胞衰老是发展代谢功能障碍和炎症的关键因素.
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