在瘦身的年轻人中,TyG指数和MASLD之间的关联:一项回顾性研究
Wenjing Xiao1, Xinghe Sun2, Hui Lv3
1Emergency Department, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, People's Republic of China.
BMC endocrine disorders
|October 2, 2025
概括
较高的甘油三糖 (TyG) 指数水平与年轻成年人代谢相关脂肪性肝病 (MASLD) 的风险增加有关. 当TyG指数超过8.3时,这种风险显著升级,观察到性别特异性模式.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 在瘦身的年轻人中,甘油三指数 (TyG) 与代谢相关的脂肪性肝病 (MASLD) 之间的关联尚未得到充分证实.
- 了解这种关系对于在这个人口群体中早期发现和管理至关重要.
研究的目的:
- 调查TyG指数与18至35岁个体中MASLD发病率之间的关系.
- 探索这种关联中的潜在非线性模式和性别特异性差异.
主要方法:
- 对20242名参与者 (18-35岁) 的腹部超声波数据的回顾性分析.
- 将TyG指数分类为四分位数和后勤回归来评估MASLD关联.
- 限制立方线的应用,以评估非线性趋势和按性别分层分析.
主要成果:
- 整体MASLD发病率为5.1%,中位数TyG指数为8.0.
- 观察到TyG指数和MASLD之间的反向L形关联,风险切断值为8.3.
- 随着TyG指数的升高,MASLD风险显著增加,特别是超过8.3,性别有显著的相互作用.
结论:
- 提升的TyG指数与年轻人群中MASLD风险增加有显著的关联.
- 当TyG指数超过8.3.3时,MASLD的风险急剧升级.
- 在TyG指数和MASLD关联中明显的性别特异性模式需要进一步调查.
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