在下肢截肢患者中,由感官脊髓刺激引起的特征性脊髓反射
Rohit Bose1,2,3,4, Ashley N Dalrymple1,5,6,7, Devapratim Sarma1,5
1Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.
Journal of neuroengineering and rehabilitation
|October 2, 2025
概括
脊髓刺激 (SCS) 可以通过激活脊髓反射来恢复下肢截肢者的感觉. 这项研究发现,SCS成功地唤起反射,而不会破坏穿行或步行对称性,在受过腿截肢的参与者中.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 康复医学 康复医学 康复医学
背景情况:
- 下肢截肢导致感觉丧失,增加跌倒风险.
- 脊髓刺激 (SCS) 已恢复截肢肢体的感觉.
- 截肢者的脊椎反射和对步态的影响是未知的.
研究的目的:
- 在下肢截肢者中描述SCS引起的脊柱反射.
- 量化SCS对步行参数的影响,如步骤周期持续时间和四肢交替对称性.
主要方法:
- 皮肤穿透式SCS电极植入3名跨腿截肢者身上.
- 电肌图 (EMG) 记录了后部根肌 (PRM) 反射.
- 使用带有和没有SCS的仪器内测量的步态参数.
主要成果:
- SCS在残余四肢肌肉中唤起了PRM反射,显示了速度依赖的抑郁.
- 反射激活发生在行走期间,而不会扰乱步行.
- 步骤周期的持续时间和四肢交替对称性在SCS和没有SCS的情况下仍然相似.
结论:
- 在跨肢截肢者中,SCS成功地激发了脊柱反射,与肌肉细胞结合.
- 在不影响步态参数的情况下,SCS还原感官反.
- SCS是一种可行的方法,可以增强下肢截肢患者的感觉反.
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