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在泰国2型糖尿病患者中,VEGF多态和糖尿病视网膜病变之间的关联

Thanyarat Promlek¹, Thanwa Wongsuk¹, Swangjit Suraamornkul²

¹Department of Clinical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.

Ophthalmic genetics

|October 2, 2025

概括

血管内皮生长因子 (VEGF) 基因多态化在-2578C/A和-634G/C时与泰国2型糖尿病患者的糖尿病视网膜病变 (DR) 风险无关. 这些VEGF变异似乎不是DR发展的重要风险因素.

科学领域:

遗传学遗传学是一个
眼科医生眼科眼科
内分泌学在内分泌学.

背景情况:

血管内皮生长因子 (VEGF) 是影响血管透性和新血管化的关键血管生成因子.
糖尿病视网膜病变 (DR) 是糖尿病的微血管并发症,导致视力受损.
在VEGF中的遗传多态性可能会影响对DR的敏感性.

研究的目的:

调查VEGF基因多态 (-2578C/A和-634G/C) 与泰国2型糖尿病患者中DR风险之间的关联.
为了确定特定的VEGF基因型或等位基因是否是DR发展的风险因素.

主要方法:

一项涉及泰国2型糖尿病患者的病例控制研究.
患者被分为糖尿病视网膜病变 (DR) 和糖尿病没有视网膜病变 (DWR) 组.
聚合酶链反应-限制片段长度多态 (PCR-RFLP) 用于基因型VEGF -2578C/A (rs699947) 和 -634G/C (rs2010963) 多态.

主要成果:

总共分析了85名患者 (37名DR,48名DWR).
在DR和DWR组之间没有观察到VEGF -2578C/A和-634G/C多态的基因型分布或等位基因频率的显著差异.
发现VEGF多态性也没有与DR发展有显著的关联.

结论:

研究的VEGF基因多态化 (-2578C/A和-634G/C) 不太可能是泰国2型糖尿病患者糖尿病视网膜病变的危险因素.
可能需要进一步的研究来探索其他导致DR的遗传或环境因素.

关键词:

在VEGF的多态化过程中,在VEGF-2578C/A中使用.在VEGF-634G/C中使用.糖尿病视网膜病变糖尿病视网膜病变

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