可食用鸟巢 - 一种具有促进皮肤修复潜力的活性
Weijuan Bai1, Fang Zheng1, Xuncai Liu1
1Bird's Nest Research Institute, Xiamen Yan Palace Seelong Biotechnology Co., Ltd., Xiamen, Fujian, China.
Biopolymers
|October 2, 2025
概括
可食用鸟巢 (EBNP) 通过减少炎症和增强细胞外基质重塑,促进皮肤组织再生和伤口愈合. EBNP含有类似于表皮生长因子 (EGF) 的活性,促进原蛋白和弹性质合成,以更快地修复皮肤.
科学领域:
- 生物化学 生化学
- 皮肤病学 皮肤病学
- 再生医学是一种再生医学.
背景情况:
- 皮肤老化和损伤是紫外线辐射和污染造成的.
- 可食用鸟巢 (EBNP) 提供抗氧化和抗炎性质,用于皮肤保护.
研究的目的:
- 调查EBNP的亲组织再生效应.
- 阐明EBNP介导的皮肤修复背后的机制.
主要方法:
- 在细胞模型和斑马鱼幼虫中评估EBNP对伤口愈合的影响.
- 分析了与结构蛋白和细胞外矩阵 (ECM) 组件相关的基因表达.
- 通过测量氧化 (NO),活性氧物种 (ROS),炎症性细胞因子 (IL-1,IL-6,TNF-α) 和中性粒细胞计数来评估EBNP的抗炎作用.
主要成果:
- EBNP含有表皮生长因子 (EGF),可以刺激伤口愈合.
- 在斑马鱼幼虫中,EBNP可对细胞中的COL1A1基因表达和col1a1b,eln1,eln2基因进行上调,从而增强ECM重塑.
- EBNP减少了NO和ROS的产生,降低了IL-1,IL-6和TNF-α水平,并降低了中性粒细胞数量,这表明它具有抗炎作用.
结论:
- EBNP通过抗炎机制和EGF类活性加速伤口愈合.
- 通过增强ECM重塑和原/弹性素合成,EBNP促进组织再生.
- EBNP显示出在食品,药品和用于皮肤修复的化品中的应用潜力.
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