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Updated: May 3, 2026

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针对向的迈克尔受体分子的简化分析方法揭示了天然的PTP1B共价抑制剂

Shih-An Wu1, Der-Yen Lee2, Geen-Dong Chang3

  • 1School of Chinese Medicine, China Medical University, Taichung, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan.

Analytical chemistry
|October 2, 2025
PubMed
概括

天然产品含有迈克尔受体分子 (MAMs),它们与蛋白质结合. 安德罗格拉菲斯 (Andrographis paniculata) 提取物,特别是奥里多宁,抑制蛋白氨酸酸酶1B (PTP1B),影响胰岛素信号传递和葡萄糖代谢.

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Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
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