相关实验视频

Updated: Jul 9, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

在突然的感觉神经听力损失中,NAD+ 增强了听力恢复:随机对照试验

Minqian Gao^1,2,3, Yingting Guan¹, Xuejing Yue¹

¹Department of Otolaryngology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

The Laryngoscope

|October 2, 2025

概括

尼古丁胺胺二核酸 (NAD+) 治疗显著改善了听力,并减少了突然感觉神经听力损失 (SSNHL) 患者的康复时间. 此外,NAD+还减轻了耳和听觉充实,提供了一个有前途的治疗选择.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
神经学神经学
生物化学生化学

背景情况:

突发感应神经听力损失 (SSNHL) 是一种复杂的疾病,有争议的最佳治疗方法.
尼古丁胺胺氨基二核酸 (NAD+) 在细胞能量代谢和修复过程中起着至关重要的作用.

研究的目的:

评估NAD+作为SSNHL辅助疗法的疗效.
为了比较接受NAD+加标准治疗和单独接受标准治疗的SSNHL患者的听力改善,恢复率和恢复时间.

主要方法:

从2022年6月到2024年6月进行了一项随机,双盲,受控的临床试验.
38名SSNHL患者被随机分为两个组:NAD+ (n=18) 和对照组 (n=20).
主要结局包括纯色平均 (PTA) 改善,恢复率 (西格尔标准) 和3个月的平均恢复时间.

主要成果:

与对照组 (23.06 dB HL,p=0.010) 相比,NAD+组的听力改善显著更大 (40.21 dB HL).
在NAD+组中,有效恢复率更高 (94.44%与60.00%,p=0.003),平均恢复时间明显更短 (62.97天与175.98天,p=0.028).
在NAD+组中, tinnitus和听觉充实度的改善更为明显,特别是在3个月后.

结论:

NAD+是一种有效的治疗方法,可以改善SSNHL患者的听力结果.
NAD+疗法加快了恢复时间,并为 tinnitus 和听觉充实等相关症状提供了额外的好处.

关键词:

这就是为什么NAD+NAD+NAD.辅酶I是一种辅酶.听力改善听力改善听力恢复时间听力恢复时间突然的感觉神经神经听力损失.

更多相关视频

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation

Published on: October 11, 2024

Sound Source Localization Testing in Single-sided Deafness Following Bone Conduction Intervention

Sound Source Localization Testing in Single-sided Deafness Following Bone Conduction Intervention

Published on: December 20, 2024

相关概念视频

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function. They...

Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.