在中国产前GBS免疫的经济评估:一个建模分析分析
Wenjing Ji1,2,3,4, Jiaxi Du1,2,3,4, Simon R Procter5
1Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Human vaccines & immunotherapeutics
|October 2, 2025
概括
在中国,为孕妇接种B组链球菌 (GBS) 疫苗可能具有成本效益. 疫苗可以将GBS病例减少49%,最佳定价取决于支付意愿的门.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 卫生经济学 卫生经济学
背景情况:
- 侵袭性B型链球菌 (GBS) 感染对全球的健康构成重大负担,特别是在新生儿中.
- 在中国,GBS疫苗的成本效益仍然未得到量化,这阻碍了潜在的实施.
研究的目的:
- 为了评估GBS疫苗在中国给孕妇的成本效益.
- 根据各种支付意愿 (WTP) 门来确定最佳的疫苗定价.
主要方法:
- 一个决策分析模型从中国医疗保健系统的角度模拟了成本和结果.
- 计算了增量成本效益比率 (ICER).
- 敏感性分析 (确定性和概率) 评估了参数不确定性.
主要成果:
- 预计GBS疫苗将使GBS病例减少49%.
- 估计的ICER是每QALY25.267美元.
- 经济有效的疫苗价格在每剂23美元至92美元之间,取决于WTP门 (人均2021年GDP的0.5倍至3倍).
结论:
- 在中国,GBS疫苗接种可能具有成本效益,WTP的门是人均GDP的3倍 (37,663美元).
- 提高疫苗的有效性和降低成本提高了成本效益.
- 建议在许可证颁发后进行预算影响分析.
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