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Updated: Jan 16, 2026

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro
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Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

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HES1通过抑制NFATc2介导的炎症来调节骨髓中介细胞功能

Anthony Z Zhu1, Zhilin Ma2, Emily V Wolff3

  • 1Division of Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA; UPMC Hillman Cancer Center, Pittsburgh, PA.

Haematologica
|October 2, 2025
PubMed
概括

毛状和增强分裂-1 (HES1) 维护骨髓中酶体 stromal 细胞 (MSC) 功能,并支持造血. 失去HES1会损害MSC,特别是在炎症性压力下,突出显示HES1.

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