在COVID感染1年后的认知功能
Joviane Daher1, Ziad Koberssy1, Jared C Durieux2
1School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Open forum infectious diseases
|October 2, 2025
概括
在COVID-19感染一年后,45岁以上成年人的认知功能没有下降. 这项研究使用客观评估跟踪了SARS-CoV-2感染后个体的认知变化.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 认知科学 认知科学
背景情况:
- 新出现的证据表明,COVID-19和认知障碍之间可能存在联系.
- 未来的纵向研究客观地评估SARS-CoV-2感染后的认知结果是缺乏的.
- 这项研究解决了COVID-19后客观认知评估的需要.
研究的目的:
- 为了评估COVID-19后的认知功能变化.
- 为了比较COVID-19感染和没有感染的个体的认知结果.
- 提供关于SARS-CoV-2的长期认知影响的客观数据.
主要方法:
- 采用了一个队列研究设计.
- 通过使用计算机化的Cognivue Clarity®设备客观测量认知功能.
- 参与者接受了基线和大约1年的随访认知评估,根据COVID-19状态分类.
主要成果:
- 在COVID-19阳性组中,只有记忆得分显示了统计学上显著的变化 (+3.9,P = .03).
- COVID-19负组在整体认知评分 (+2,P = .03) 和子域中表现出改善.
- 在COVID-19阳性和阴性组之间,在整体认知得分或子域中没有发现显著差异.
结论:
- 在COVID-19感染后的一年,在平均45岁人口中没有观察到认知能力下降.
- 客观认知评估没有显示出这一群体的长期损害.
- 研究结果表明,COVID-19感染可能不会导致该人口群体一年后认知功能的可测量下降.
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