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没有证据表明MMR诱导训练免疫来预防SARS COV2:来自多中心RCT的结果

Sinead Delany-Moretlwe¹, Hakim-Moulay Dehbi², Izukanji Sikazwe³

¹Wits RHI, University of Witwatersrand, Johannesburg, South Africa.

Frontiers in immunology

|October 2, 2025

概括

含麻疹疫苗 (MCV) 在临床试验中没有预防COVID-19或SARS-CoV-2感染. 这表明训练有素的免疫刺激可能不会在未来的流行病中有效预防呼吸道疾病.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
传染性疾病传染性疾病

背景情况:

含麻疹疫苗 (MCV) 假设可以增强先天免疫力,可能防止SARS-CoV-2感染和COVID-19.
训练免疫的概念表明,疫苗可以激活非特异性免疫系统.

研究的目的:

评估MCV在预防症状性COVID-19和SARS-CoV-2感染方面的有效性.
为了确定使用MCV刺激训练免疫力是否能提供对呼吸道病毒感染的保护.

主要方法:

一项国际双盲,安慰剂对照试验,涉及18岁及以上的成年人.
参与者被随机分配,接受MCV或盐酸安慰剂.
主要结局:PCR确认的症状性COVID-19在60天内. 二次结果:PCR确认的症状性COVID-19和血清学确认的SARS-CoV-2感染在150天内.

主要成果:

在60天 (1.5%对1.2%) 或150天 (4.1%对4.1%) 的MCV和盐酸组之间,症状性COVID-19发病率没有显著差异.
在试验期间,SARS-CoV-2感染率在各组之间也相似 (10.6%对10.3%).
由于COVID-19而入院的病例较低,并且在两组之间可比.

结论:

用于诱导训练免疫的MCVs的管理并没有防止COVID-19或SARS-CoV-2感染.
刺激训练有素免疫力的策略可能对预防呼吸系统疾病没有好处,包括在未来的流行病期间.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.麻疹是一种麻疹.麻疹含有含有疫苗的疫苗.麻疹麻疹是一个预防预防预防红疹是一种红疹.训练有素的免疫力

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