一个离散选择实验分析,以了解患者对多发性骨髓瘤治疗的偏好
Beth Faiman1, Hoa H Le2, Julie Laurent3
1Cleveland Clinic, Cleveland, OH, United States.
Frontiers in oncology
|October 2, 2025
概括
患有复发性/耐药性多发性骨髓瘤 (RRMM) 的患者优先考虑治疗疗效,包括无进展生存期 (PFS) 和整体生存期 (OS),而不是某些不良事件,如细胞因子释放综合征 (CRS). 了解这些偏好是RRMM管理中共享决策的关键.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 患者报告的结果
背景情况:
- 多发性骨髓瘤 (MM) 是一种血细胞恶性瘤,需要对复发性/耐药性病例 (RRMM) 进行有效管理.
- 随着RRMM治疗的进步,出现了新的治疗选择,需要了解患者的偏好.
研究的目的:
- 调查患者对复发性/耐药性多发性骨髓瘤的各种治疗属性的偏好.
- 确定对RRMM患者的疗效结果和不良事件的相对重要性.
主要方法:
- 一个描述性的,使用在线离散选择实验 (DCE) 的横截面研究.
- 从美国的成年RRMM患者收集的数据 (2023年11月 - 2024年3月).
- 分析涉及条件后勤 (CL) 回归和相对属性重要性 (RAI) 计算.
主要成果:
- 患者优先考虑了更长的无进展生存期 (PFS) 和整体生存期 (OS) (RAI: 36.4%) 和更高的整体应答率 (ORR) (RAI: 22.1%).
- 值得关注的不良事件包括细胞因子释放综合征 (CRS) (RAI: 15.2%) 和感染 (RAI: 11.9%).
- 患者愿意接受更高的CRS风险以改善ORR,这表明他们更喜欢权衡.
结论:
- 在不断变化的RRMM治疗环境中,患者偏好强烈支持治疗疗效 (PFS,OS,ORR).
- 了解患者对治疗属性的评估对于共享决策和优化临床结果至关重要.
- 这项研究提供了对治疗复发性/耐药性多发性骨髓瘤的患者优先事项的见解.
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