禁食时间对COVID-19感染后死亡率的影响:单一机构的回顾性分析
Naoko Takaku1,2, Koji Hayashi1, Hiromi Hayashi1
1Department of Rehabilitation Medicine, Fukui General Hospital, Fukui 9108561, Japan.
Infectious medicine
|October 2, 2025
概括
长时间的禁食时间与COVID-19患者的死亡风险增加有关. 早期康复干预可以改善这些患者的临床结果.
科学领域:
- 医疗康复 医疗康复
- 传染性疾病 传染性疾病
- 临床营养学 临床营养学
背景情况:
- 禁食的持续时间会影响吸气性肺炎的恢复.
- 严重的COVID-19,禁食和患者预后之间的联系尚未得到充分理解.
- 这项研究调查了禁食时间对COVID-19死亡率的影响.
研究的目的:
- 为了确定禁食时间对COVID-19感染后患者死亡率的影响.
- 分析禁食时间与患者结果之间的关系.
- 为了确定与COVID-19死亡率相关的因素.
主要方法:
- 在COVID-19后接受康复的102名患者的回顾性分析 (2021年3月至2023年6月).
- 提取的数据包括人口统计,并发症 (查尔森并发症指数),认知功能,护理水平和营养状况 (白蛋白).
- 使用后勤回归分析来评估禁食时间和死亡率之间的关联,并对混因素进行调整.
主要成果:
- 禁食时间 (OR: 1.01,95% CI: 1.01-1.11) 和年龄 (OR: 1.07,95% CI: 1.001-1.15) 是 COVID-19 结果的显著独立预测因素.
- 在禁食时间超过5天的患者中,更高的护理水平 (OR: 1.65,95% CI: 1.24-2.20) 和临床结果 (OR: 9.19,95% CI: 2.80-30.20) 是显著的.
- 31名患者死亡,71人幸存下来.
结论:
- 禁食时间是COVID-19感染后死亡的独立风险因素.
- 早期康复干预对于改善COVID-19后患者的临床结果至关重要.
- 管理禁食时间可能是减轻死亡风险的关键.
相关概念视频
Metabolic States of the Body: Fasting and Starvation
2.6K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
2.6K
Metabolic States of the Body: The Postabsorptive State
1.2K
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
1.2K
Bioavailability Study Design: Healthy Subjects Versus Patients
126
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
126
Overview of Carbohydrate Metabolism
3.1K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
3.1K
Censoring Survival Data
495
Survival analysis is a statistical method used to analyze time-to-event data, often employed in fields such as medicine, engineering, and social sciences. One of the key challenges in survival analysis is dealing with incomplete data, a phenomenon known as "censoring." Censoring occurs when the event of interest (such as death, relapse, or system failure) has not occurred for some individuals by the end of the study period or is otherwise unobservable, and it might have many different...
495

