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炎症性肠病中的症状集群:范围审查
Keying Xu1, Mengjiao Li1, Ping Jiang1,2
1Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Frontiers in medicine
|October 2, 2025
概括
在炎症性肠病 (IBD) 中调查症状集群揭示了显著的异质性. 标准化工具和进一步的研究对于理解这些复杂的症状组和改善IBD患者护理至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 临床研究 临床研究
- 患者报告的结果
背景情况:
- 炎症性肠病 (IBD) 是一种具有高症状负担的慢性疾病,通常具有多个同时出现的症状.
- 目前的研究经常单独检查IBD症状,忽视症状集群的复杂性.
- 了解IBD症状集群对于全面的患者管理方法至关重要.
研究的目的:
- 进行范围审查,综合现有关于IBD症状集群类型的证据.
- 确定IBD症状集群的评估工具,相关因素和动态轨迹.
- 突出IBD症状集群的当前研究中的差距和不一致性.
主要方法:
- 使用Arksey和O'Malley的框架进行了范围审查.
- 搜索涉及到2024年10月31日之前的数据库开始.
- 包括的研究被分析,以识别和分类症状集群.
主要成果:
- 13项研究确定了29个不同的症状集群,显示出明显的异质性和重叠.
- 集群被分为五组:胃肠道/身体,心理,全身/疲劳,营养/食欲相关,混合/轨迹相关.
- 评估工具缺乏IBD特定验证,相关因素报告不一致,纵向变化很少被研究.
结论:
- 对IBD症状集群的研究有限且异质,需要标准化的定义和验证的工具.
- 对于性结肠炎 (UC) 和克罗恩病 (CD) 可能存在不同的聚类模式,需要对亚型进行特定分析.
- 未来的研究应该采用纵向,生物标志物知情的设计来检查集群相互作用并增强临床管理.
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