微生物组工程来增强水产养殖中的抗病能力:当前的战略和未来的方向
Muhammad Tayyab1, Yongzhen Zhao2, Yueling Zhang1
1Institute of Marine Sciences and Guangdong Provincial Key Laboratory of Marine Biology, Shantou University, Shantou, China.
Frontiers in microbiology
|October 2, 2025
概括
微生物组工程通过使用精密益生菌和生态策略来增强水生动物疾病抵抗力. 这种可持续的方法解决了水产养殖业面临的挑战,以改善粮食安全和气候适应力.
科学领域:
- 水产养殖和微生物生态学
- 可持续的粮食安全 可持续的粮食安全
- 动物健康和疾病耐药性
背景情况:
- 水产养殖面临疾病,抗菌素耐药性和生态破坏的威胁,影响全球粮食安全.
- 传统的益生菌和益生菌表现出不一致的现场疗效,需要适应气候的解决方案.
- 微生物组工程提供了一种可持续的策略,以加强水生动物的抗病能力.
研究的目的:
- 综合微生物组工程的进步,以提高水产养殖中的抗病能力.
- 解决传统益生菌/益生菌前期疗效的差距,以及需要适应气候变化的水产养殖解决方案.
- 突出精确微生物组工程作为一个整合多omics和AI的变革性范式.
主要方法:
- 对160多项关于水产养殖中的微生物组工程研究的叙事分析.
- 整合基因组学,代谢学,CRISPR和人工智能,以确定弹性战略.
- 识别与健康相关的微生物和代谢物作为针对性干预的生物标志物.
主要成果:
- 精密微生物组工程利用量身定制的益生菌 (例如,基因组编辑的Bacillus subtilis) 和益生菌 (例如,奇托寡糖).
- 协生菌和生态合理的创新,如便微生物群移植,显示了抑制病原体和免疫调节的潜力.
- 主体微生物群的兼容性和生态风险是农场翻译的关键挑战.
结论:
- 精确的微生物组工程,集成多omics和AI,为水产养殖健康提供量身定制的解决方案.
- 基于生态的干预措施和合成联盟增强疾病控制和微生物群稳定性.
- 政策与可持续发展目标的协调对于在水产养殖中可持续采用微生物组工程至关重要.
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