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Updated: Jan 16, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
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针对抗莱什曼病治疗的天然产品结构改造的最新进展 (2010-2024年)

Fu-Qun Sun1, Yin-Sheng Quan1, Qing-Kun Shen1

  • 1Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University Yanji 133002 China Yinxm@ybu.edu.cn zsquan@ybu.edu.cn.

RSC medicinal chemistry
|October 2, 2025
PubMed
概括

天然产品的结构改造显著增强了抗莱什曼病毒的活性,产生了具有纳米分子功效和更高安全性的强效衍生物. 本综述强调了开发针对莱什曼病的新型治疗方法的进展.

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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