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Updated: Jan 16, 2026

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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Published on: December 11, 2017

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基于通路响应基因组的化学疗法耐药性药物发现及其在乳腺癌中的应用

Dehua Feng1, Jingwen Hao2, Lingxu Li1

  • 1School of Intelligent Medicine and Technology, Kidney Disease Research Institute, Hainan Engineering Research Center for Health Big Data, Hainan Medical University, Haikou, Hainan, China.

Frontiers in bioinformatics
|October 2, 2025
PubMed
概括

我们开发了通路响应基因组 (PRGS) 来识别癌症药物耐药性通路. PRGS精确检测动态基因变化,指导开发新型组合疗法,如博尔特佐米布 - 布莱米辛,以改善患者的治疗结果.

关键词:
耐化疗耐药性 耐化疗耐药性药物组合治疗是药物组合治疗.发现药物的发现.路径响应基因组的路径响应基因组.精确瘤学 精确瘤学

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