菌是促进性因素,而不是诱导性因素导致口腔癌吗?
Xu Wang1,2,3, Xinming Zhang1,2,3, Shuangshuang Wu1,2
1Department of Oral Medicine, Peking University School and Hospital of Stomatology, Haidian District, Beijing, China.
Journal of oral microbiology
|October 2, 2025
概括
单独的Candida albicans很少引起口腔癌,但当与吸烟相结合时,它可以加速恶性转变. 这项研究探讨了其致癌潜力,并发现它可以调节与癌症相关的基因.
科学领域:
- 口腔瘤学 在口腔瘤学
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 菌与癌症有关,但其在口腔癌发展中的直接作用尚不清楚.
- 研究C. albicans与口腔癌发生之间的关联对于了解癌症病因至关重要.
研究的目的:
- 探索Candida albicans在口腔癌中的致癌潜力.
- 确定C. albicans是否可以直接诱导口腔癌或影响其发展.
主要方法:
- 转录基因组测序 (mRNAseq) 和全外基因组测序 (WES) 用于分析长期C. albicans刺激对小鼠模型口腔粘膜的影响.
- 4 - 尼托基诺林-1-氧化物 (4NQO) 用于研究C. albicans和吸烟的联合作用.
- 在慢性多发性候群病 (CHC) 组织中表现出体质突变.
主要成果:
- 长期刺激C. albicans并没有直接诱导口腔癌,但显著上调了与细胞增殖和癌症发展相关的基因.
- 对CHC的分析显示,Candida和吸烟可能共同导致癌前病变.
- 刺激C. albicans激活了炎症和免疫反应途径,并促进了4NQO治疗小鼠的癌症形成.
结论:
- 单独C. albicans在口腔粘膜中具有有限的直接致癌潜力.
- C. albicans可以加速口腔恶性转变,特别是在与吸烟或其他致癌物质相结合时.
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