血红蛋白与红细胞分布宽度比率与中国成年人的抑郁症之间的关联:基于人口的横截面研究
Yike Xu1, Shuwen Zhang2,3, Yang Liu4
1West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in public health
|October 2, 2025
概括
血红蛋白与红细胞分布宽度比 (HRR) 与中国成年人的抑郁症状相反相关. 较高的HRR水平与较低的抑郁症状风险相关,特别是在老年人中.
科学领域:
- 血液学 血液学 血液学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 抑郁症状在全球范围内构成了重大公共卫生挑战.
- 生物标志物对于早期检测和抑郁症状的风险分层至关重要.
- 血红蛋白与红细胞分布宽度比 (HRR) 已成为一个潜在的指标.
研究的目的:
- 在一大批中国成年人中调查HRR与抑郁症状升高之间的关联.
- 探索对这种关联的潜在影响修饰因素,如年龄.
- 评估HRR作为抑郁症状风险的潜在生物标志物.
主要方法:
- 从例行健康检查中对30,427名成年人的横截面分析.
- 使用自我评价抑郁症尺度 (SDS ≥53) 评估抑郁症.
- 进行了多变量逻辑回归,受限立方线和灵敏度分析,并对混因素进行了调整.
主要成果:
- 在HRR和抑郁症状升高 (SDS≥53) 之间发现了显著的逆分级关联.
- 每个HRR单位的增加都与高抑郁症状减少39%有关 (OR=0.61).
- 在45岁及以上的成年人中,HRR的保护作用更为明显.
结论:
- HRR可以作为中国成年人抑郁症状升高的独立,具有成本效益的生物标志物.
- HRR可以帮助风险分层和预防策略,特别是在老龄化人口中.
- 需要进一步的前性研究来验证这些发现.
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