炎症和基于营养的指标和糖尿病足的关联:一个横截面研究和一个回顾性研究
Hua Chen1, Yu Zhou2, Jiezhi Dai1
1Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, JiaoTong University, Shanghai, China.
Frontiers in endocrinology
|October 2, 2025
概括
高的中性粒细胞-白蛋白比率 (NAR),单细胞-白蛋白比率 (MAR) 和红细胞分布宽度-白蛋白比率 (RAR) 表明糖尿病足 (DFU) 风险增加. 相反,低血红蛋白,白蛋白,淋巴细胞和血小板 (HALP) 评分和预后营养指数 (PNI) 与更高的DFU患病率有关.
科学领域:
- 生物标志物和健康问题
- 糖尿病研究 糖尿病研究
- 伤口治愈研究 伤口治愈研究
背景情况:
- 炎症和营养状况对于糖尿病损害的伤口愈合至关重要.
- 炎症和营养指标与糖尿病足 (DFU) 之间的具体联系仍未得到充分探索.
研究的目的:
- 调查炎症和基于营养的指标与DFU的患病率之间的关联.
- 分析这些关联的非线性关系和子组稳定性.
主要方法:
- 利用了来自NHANES数据库 (1999-2004) 的31,126个人的横截面分析.
- 检查了中性粒细胞-白蛋白比率 (NAR),单细胞-白蛋白比率 (MAR),红细胞分布宽度-白蛋白比率 (RAR),血红蛋白,白蛋白,淋巴细胞和血小板 (HALP) 评分,以及预后营养指数 (PNI).
- 采用二进制物流回归和受限立方线分析,并补充了一项回顾性临床研究.
主要成果:
- 较高的NAR,MAR和RAR三地动物与DFU患病率 (ORs从1.73到4.47) 有积极的关联.
- 高HALP和PNI三角形显示出与DFU患病率的负相关性 (ORs从0.42到0.50不等).
- 限制立方线分析显示了RAR和DFU之间的非线性关系,RAR显示出卓越的预测能力.
结论:
- 升高的NAR,MAR和RAR是DFU的危险因素.
- 减少HALP和PNI与DFU患病率的增加有关.
- RAR显示出作为DFU预测生物标志物的巨大潜力.
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