平安粉可以通过调节微生物代谢物SCFA来缓解高脂肪饮食引起的结肠炎症
Tangjuan Liu1, Guosen Ou1, Jialin Wu1,2
1School of Traditional Chinese Medicine, Jinan University, Guangzhou, China.
Frontiers in cellular and infection microbiology
|October 2, 2025
概括
平安威粉 (PWP) 通过促进有益的肠道细菌,如Alistipes和Parabacteroides,增加乳糖酸,并抑制PI3K/AKT/mTOR途径来促进结肠自和减少炎症来缓解性结肠炎 (UC).
科学领域:
- 综合医学是一个整体的医学.
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 性结肠炎 (UC) 是一种具有复杂病原性的慢性炎症性疾病.
- 传统中医 (TCM) 和平威粉 (PWP) 一样,显示出对UC的治疗潜力.
- 在UC中PWP的精确机制,特别是它与肠道微生物群的相互作用,需要阐明.
研究的目的:
- 在UC模型中研究PWP对高脂肪饮食引起的结肠炎症的治疗作用.
- 探索PWP对肠道微生物群组成和功能的监管机制.
- 阐明PI3K/AKT/mTOR途径和自在PWP疗效中的作用.
主要方法:
- 网络药理学确定了UC的潜在PWP目标.
- 组织学,免疫光和西部斑分析评估了结肠组织变化和蛋白质表达.
- qRT-PCR测量了炎症性细胞因子;16S rDNA测序和GC/MS分析了肠道微生物群和短链脂肪酸 (SCFA);便微生物群移植 (FMT) 和丁酸盐补充验证了机制.
主要成果:
- 在PWP治疗下调PI3K,pAKT/AKT和pmTOR/mTOR,表明PI3K/AKT通路的抑制.
- PWP增强了结肠上皮细胞自,由改变的P62和LC3B-II/LC3B-I水平证明.
- PWP增加了SCFA产生细菌 (Alistipes,Parabacteroides) 的丰富性,并提高了肠道SCFA水平.
结论:
- 通过调节肠道微生物群和抑制PI3K/AKT/mTOR通路,PWP有效地改善了UC中的结肠炎症.
- 由特定的肠道细菌介导的SCFA产量增加,特别是乳酪酸盐,是PWP治疗作用的关键机制.
- PWP促进结肠自,有助于解决炎症,并突出其作为UC新治疗策略的潜力.
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