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在卵巢切除的小鼠中,有氧运动方式对肠道微生物群和骨肌肉质量的影响
Tao Li1, Yongjun Lu2, Fangfang Yu1
1School of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Frontiers in cellular and infection microbiology
|October 2, 2025
概括
有氧运动通过改善蛋白质代谢,增强局部雌激素和积极改变肠道微生物群组成来增强卵巢切除小鼠的骨肌肉质量和功能,为绝经后妇女提供了洞察力.
科学领域:
- 运动生理学 运动生理学
- 肌肉生物学 肌肉生物学
- 微生物组研究 微生物组研究
背景情况:
- 小鼠的卵巢切除 (OVX) 模仿绝经后的情况,导致骨肌质量下降.
- 绝经后雌激素的下降会导致肌肉缩和代谢变化.
- 肠道微生物群的改变越来越多地与宿主健康有关,包括肌肉功能.
研究的目的:
- 研究有氧运动对OVX小鼠骨肌肉,肠道微生物群和雌激素的影响.
- 阐明运动效益背后的分子机制.
- 为绝经后妇女提供运动干预措施的证据.
主要方法:
- 卵巢切除和假老鼠经历了8周的跑步机炼.
- 分析了肌肉形态,功能 (抓捕测试) 和蛋白质通路 (西方斑).
- 评估了芳酶,雌激素水平和肠道微生物群组成 (16S rRNA测序).
主要成果:
- 有氧运动改善了OVX小鼠的肌肉质量,纤维大小和握力.
- 运动增加了局部雌激素合成,并激活了Akt/mTOR通路,抑制了蛋白质降解.
- 运动增强了肠道微生物多样性和改变了社区结构,与肌肉功能有积极的相关性.
结论:
- 通过改善蛋白质代谢和局部雌激素合成,有氧运动对OVX小鼠的骨肌肉有好处.
- 通过运动调节肠道微生物群的组成,在增强肌肉质量和功能方面发挥着作用.
- 研究结果支持运动作为减轻绝经后妇女肌肉损失的策略.
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