与年龄相关的Bifidobacterium菌株对肠道免疫和微生物多样性的免疫微环境依赖的影响
Yaqin He1, Furui Zhang2, Zhiqiang Tian3
1General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Frontiers in cellular and infection microbiology
|October 2, 2025
概括
两种Bifidobacterium菌株,Bifidobacterium adolescentis (BA) 和Bifidobacterium longum亚种. 这两种菌株都被认为是Bifidobacterium longum亚种. 婴儿 (BI),对肠道免疫产生明显的免疫调节作用. BI直接激活γδ T细胞,而BA通过微环境机制影响免疫反应,为个性化的益生菌疗法提供了洞察力.
科学领域:
- 肠道微生物群研究研究
- 免疫学 免疫学 免疫学
- 益生菌科学是一种益生菌科学.
背景情况:
- 双杆菌对肠道健康至关重要,但与年龄相关的菌株对免疫力的影响尚不清楚.
- 益生菌的应用越来越多,需要对其机制有更深入的了解.
- 肠道免疫和微生物多样性是复杂的,并受到细菌物种的影响.
研究的目的:
- 研究Bifidobacterium adolescentis (BA) 和Bifidobacterium longum亚种的免疫调节作用. 婴儿婴儿 (BI).
- 在各种模型中分析对肠道免疫和微生物多样性的影响.
- 探索潜在的治疗应用的菌株特异性作用机制.
主要方法:
- 使用了DSS诱导的慢性结肠炎小鼠模型,无菌小鼠和体外人类肠道 γδ T 细胞共同培养.
- 进行了转录组和RNA-seq分析,以评估基因表达变化.
- 进行了多omics相关性分析,以了解免疫调节机制.
主要成果:
- 在大肠炎模型中,BA和BI都减少了gδT细胞透,并调节了免疫标记物.
- BA激活了NOD2类受体信号,而BI增强了IL-17和TNF信号通路.
- 乙直接激活了γδ T细胞,而乙的影响则取决于微环境.
结论:
- 研究结果支持与年龄相关的益生菌干预措施,以促进免疫健康和肠道平衡.
- 独特的菌株特异性机制为个性化微生物群调节提供了洞察力.
- 结果为开发针对炎症性疾病的向益生菌策略提供了理论基础.
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