支气管病患者的支气管洗液中的潜在微生物:细菌,非结核菌菌和真菌
Lam Nguyen-Ho1,2,3,4, Quoc-Khanh Tran-Le1, Hoang Kim Tu Trinh5
1Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
支气管切除症患者在支气管洗液中表现出高比例的非结核性真菌菌 (NTM) 和多药耐药细菌. 早期NTM检测可能表明较轻的疾病和潜在的未来进展.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 支气管切开症是一种慢性肺部疾病,伴有不可逆转的支气管扩张和频繁的感染.
- 在稳定的支气管切除症患者中,支气管洗液 (BLF) 的微生物学分析比唾液研究少.
- 非结核性真菌菌 (NTM) 越来越多地与支气管切除症的进展有关.
研究的目的:
- 在稳定的支气管切除症患者中调查BLF的微生物学概况.
- 确定这些患者在BLF中NTM检测率.
- 探索NTM检测和疾病严重程度之间的关系.
主要方法:
- 一项前性多中心观察性研究,涉及99名成年支气管切除症患者.
- 在2023年1月至2024年1月的支气管镜检查期间采集的BLF样本.
- 进行细菌和真菌培养;使用多重聚合酶链反应 (PCR) 检测NTM.
主要成果:
- 在52.5%的患者中检测到NTM,主要是生长缓慢的物种.
- 在41.9%的病例中发现了细菌感染,多种耐药性 (MDR) 生物体的流行率很高,如 *Klebsiella pneumoniae*.
- 在24.6%的病例中发现了真菌病原体.
- 更高的支气管切除症严重程度与细菌感染增加相关,但NTM检测减少.
结论:
- BLF分析揭示了越南支气管病患者的显著微生物多样性,包括NTM和MDR细菌.
- 高的NTM检测率,特别是在较轻的疾病中,表明潜在的早期诊断价值.
- 建议使用先进的分子技术进行常规,全面的微生物评估,以有效管理支气管切除症.
更多相关视频
06:57The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
Published on: May 8, 2017
10:26P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives
Published on: June 15, 2020
相关概念视频
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia III: Complications and Assessment
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
Sputum Studies II: Culture and Sensitivity
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
