跨国人口中干脂肪质量指数和糖尿病之间的关联
Chibueze Ogbonnaya1, Madison Kindred2, Carl J Lavie3
1Population, Policy and Practice Research and Teaching Department, University College London, London, United Kingdom.
Mayo Clinic proceedings. Innovations, quality & outcomes
|October 2, 2025
概括
高干脂肪质量指数 (TFMI) 与糖尿病风险增加有关,即使在相同的身体质量指数 (BMI) 类别内. 这种关联在正常体重,超重和肥胖个体中都是正确的,突出了中央脂肪作为糖尿病的主要预测因素.
科学领域:
- 内分泌学和新陈代谢学
- 公共卫生和流行病学
- 身体组成分析 身体成分分析
背景情况:
- 身体质量指数 (BMI) 是用于体重分类的常见指标,但它没有区分脂肪分布.
- 中部脂肪,特别是干脂肪,越来越被认为是代谢疾病的重要危险因素.
- 了解不同BMI类别的干脂肪与糖尿病风险的独立关联对于公共卫生至关重要.
研究的目的:
- 为了研究干脂肪质量指数 (TFMI) 和糖尿病之间的截面关系.
- 在跨国队列中,在定义的身体质量指数 (BMI) 类别中专门分析这一关联.
- 为了确定升高的干部脂肪是否独立地预测糖尿病风险,无论整体BMI.
主要方法:
- 汇集了来自英国,美国和韩国的57,764名40岁以上的个人数据.
- 使用双能X射线吸收计 (DXA) 评估的车身脂肪质量.
- 糖尿病患病率通过自我报告的病史确定,并通过血生物化学证实.
主要成果:
- 在所有BMI类别 (正常体重,超重,肥胖) 中,观察到一个显著的线性趋势,即增加患糖尿病的风险与更高的TFMI.
- 在正常体重的个体中,TFMI五分位数最高的个体患糖尿病的风险大约是最低五分位数的3倍,相比之下,正常体重的个体患糖尿病的风险大约是3倍.
- 在正常体重,超重和肥胖分类中,高TFMI始终预测男性和女性患糖尿病的风险更高.
结论:
- 高干脂肪量是糖尿病的重要预测因素,独立于整体体重指数.
- 中枢脂肪在糖尿病的发展中起着至关重要的作用,即使在BMI正常或高的人中也是如此.
- 为了更全面地评估糖尿病风险,应考虑与BMI一起考虑TFMI.
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