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相关概念视频

The Physiology of Taste01:24

The Physiology of Taste

7.2K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
7.2K
Gustation01:43

Gustation

51.9K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
51.9K
Taste Buds and Receptors01:20

Taste Buds and Receptors

4.6K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
4.6K

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相关实验视频

Updated: Jan 16, 2026

Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults
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通过基于TAS1R2/TAS1R3的模型预测的甜度得分来量化人类的甜味感知.

Ajung Kim1, Yiseul Kim1, Nayoung Choi1

  • 1Division of Food Functionality Research, Korea Food Research Institute, Wanju 55365, Republic of Korea.

Food chemistry: X
|October 2, 2025
PubMed
概括

一个新的成像系统通过量化受体反应来客观地测量人工甜味剂的功效. 这种模型预测的甜度得分 (MPSS) 与相对甜度有很强的相关性,为主观感官面板提供了替代方案.

关键词:
人工甜味剂 人工甜味剂在EC50 EC50中,我们可以使用EC50反向回归是一种反向回归.模型预测的甜度得分 (MPSS)定量预测可以预测数量.相对的甜度 相对的甜度甜味受体是一种甜味的受体.

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Taste Exam: A Brief and Validated Test
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Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test
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Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test

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相关实验视频

Last Updated: Jan 16, 2026

Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults
09:17

Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults

Published on: July 16, 2016

18.1K
Taste Exam: A Brief and Validated Test
07:10

Taste Exam: A Brief and Validated Test

Published on: August 17, 2018

17.1K
Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test
08:52

Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test

Published on: April 21, 2021

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科学领域:

  • 生物化学 生物化学
  • 感官科学 感官科学
  • 分子生物学分子生物学

背景情况:

  • 人造甜味剂提供低热量的甜味,但使用主观感官面板进行评估.
  • 关键的基准,如甜度强度和感知值,对于甜味剂的评估至关重要.
  • 需要开发一个客观的,受体水平的方法来补充或取代感官分析.

研究的目的:

  • 开发一个客观的,基于受体的系统来量化人工甜味剂的反应.
  • 为了建立受体活性和感知甜味之间的相关性.
  • 创建基于分子相互作用的甜味的预测模型.

主要方法:

  • 使用HEK293T细胞开发了一个基于TAS1R2/TAS1R3的成像系统.
  • 对五种不同的人工甜味剂的量化受体反应.
  • 从剂量反应曲线中确定EC50 (效力) 和最大响应 (疗效).
  • 在EC50和报告的相对甜度 (RS) 之间进行逆回归分析.

主要成果:

  • 在EC50和相对甜度 (RS ≈ 1.38/EC50) 之间发现了强烈的相关性 (R2 = 0.9688).
  • 开发了一个基于EC50的模型预测甜度得分 (MPSS),与已知的RS值密切匹配.
  • 此外,MPSS值也反映了报告的味道检测值.
  • 最大受体反应与相对甜度的相关性不佳.

结论:

  • 基于EC50的建模为预测甜味提供了受体水平的感知接地方法.
  • 开发的系统和MPSS为甜味剂研究中的传统感官评估提供了实用,客观的替代方案.
  • 这种方法促进了食品科学和分子生物学中的客观量化.