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帕金森病视觉唤起潜力和光学一致性断层扫描的变化:系统性审查和元分析

Zahra Hemmatian^1,2, Javad Heravian Shandiz^2,3, Ali Shoeibi⁴

¹Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.

Parkinson's disease

|October 2, 2025

概括

帕金森病患者表现出显著的视网膜神经纤维层稀释和延长的P100延迟. 这些发现,通过对OCT和VEP测试的分析得到证实,突出显示了PD视觉路径受损.

科学领域:

眼科医生眼科眼科
神经学神经学
医疗成像医学成像
神经科学是一个神经科学.

背景情况:

之前的研究表明,在帕金森病 (PD) 患者中,光学连贯性断层扫描 (OCT) 和视觉唤起潜力 (VEP) 的潜在损害,但研究结果不一致.
本次元分析旨在通过检查在同一患者队列中使用OCT和VEP的研究来澄清这些不一致性.

研究的目的:

系统地评估和综合现有证据,比较健康对照对帕金森病患者的OCT和VEP变化.
为了确定帕金森病是否与视网膜神经纤维层 (RNFL) 厚度和P100延迟的显著变化有关.

主要方法:

在PubMed,Scopus,Cochrane和谷歌学者数据库中进行了全面的文献搜索.
包括的研究比较了帕金森病患者和健康对照组之间的OCT和VEP参数.
聚合加权平均差异是使用随机效应模型进行元分析来计算的.

主要成果:

分析了10项涉及337名PD患者和273名对照者的研究.
患有PD的患者表现出显著延长的P100延迟 (平均差异 = 6.16毫秒,p=0.02) 和显著的RNFL稀释 (平均差异 = -4.38微米,p ≤0.001).
在P100振幅 (p=0.06) 或中央骨厚度 (p=0.08) 中没有发现显著差异. 在RNFL厚度和P100延迟之间观察到负相关性 (r=-0.65,p ≤ 0.001).

结论:

分析证实了帕金森病患者显著的RNFL稀释和延长的P100潜伏期.
这些发现支持PD视觉通路功能障碍的存在,可通过OCT和VEP测量.

关键词:

帕金森病是帕金森病的一种.光学连贯性断层扫描 (optical coherence tomography) 是一种光学连贯性断层扫描技术.视觉唤起的潜在潜力

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