大脑辐射死亡症成功地用高剂量贝瓦西祖马布治疗
Keiichi Kugimiya1, Hironobu Tsubouchi1, Kiyotaka Saito2
1Division of Respirology, Rheumatology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan.
Respiratory medicine case reports
|October 2, 2025
概括
在立体射线外科手术 (SRS) 后的大脑辐射亡 (CRN) 被抗VEGF抗体bevacizumab成功治疗. 六个周期的贝瓦西祖马布可以防止长期的CRN复发.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 大脑辐射亡 (CRN) 是焦点辐射疗法的晚期并发症,特别是立体辐射手术 (SRS).
- 过度的血管内皮生长因子 (VEGF) 生产是CRN的潜在原因.
- 抗VEGF抗体贝瓦西祖马布是一种潜在的CRN治疗方法.
研究的目的:
- 报告SRS后成功治疗CRN的bevacizumab病例.
- 评估贝瓦西祖马布在治疗CRN的疗效和长期结果.
主要方法:
- 一名71岁的男性患有CRN后SRS转移性肺腺癌的治疗.
- 治疗涉及六个周期的贝瓦西祖马布 (15毫克/公斤每3周).
- 评估了神经症状和MRI发现 (加多增强,T2-FLAIR高强度).
主要成果:
- 贝瓦西祖马布治疗导致神经症状 (失语,软弱) 显著改善.
- 核磁共振显示了加多增强病变和T2-FLAIR超强度的解消.
- 在治疗后44个月内,神经系统的改善持续了44个月.
结论:
- 贝瓦西祖马布是一种有效的CRN治疗选择.
- 六个周期的贝瓦西祖马布可以提供长期保护,防止CRN复发.
- 需要进一步的研究来确定贝瓦齐祖马布在CRN治疗中的最佳剂量和持续时间.
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