基于内型的慢性鼻炎的治疗方法:东方和西方之间的差异
Junhai Chen1,2,3, Linlu Wang1,2,3, Xinyue Wang1,2,3
1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
概括
慢性鼻炎与鼻息肉 (CRSwNP) 管理的差异源于炎症的地理差异. 西方CRSwNP患者经常患有2型 (T2) 炎症,而东方患者主要表现出非T2炎症,需要不同的治疗方法.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在全球范围内,具有鼻息肉的慢性鼻鼻炎 (CRSwNP) 呈现出显著的异质性.
- 西部CRSwNP种群的特点是2型 (T2) 炎症的高患病率.
- 东部CRSwNP种群主要存在非T2炎症内型.
研究的目的:
- 突出基于地理和炎症内型差异的CRSwNP独特的管理策略.
- 强调精确的T2炎症识别对于优化CRSwNP治疗结果的重要性.
- 为了区分T2炎症偏差与非T2炎症主导CRSwNP的治疗方法.
主要方法:
- 在西方和东方国家对CRSwNP患者群体的比较分析.
- 根据已识别的内型,审查当前的治疗指南和治疗选择.
- 关于T2炎症在CRSwNP病原和管理中的作用的文献综合.
主要成果:
- 2型炎症是西方CRSwNP患者的主要内型.
- 非T2炎症是东部CRSwNP患者观察到的主要内型.
- 量身定制的治疗包括葡萄皮质类药物,手术和T2生物药物用于T2偏差的CRSwNP,以及对非T2主导的CRSwNP的宏类药物.
结论:
- 地理变异显著影响CRSwNP内型和随后的管理策略.
- 准确诊断T2炎症对于有效的CRSwNP治疗个性化至关重要.
- 对于T2高和T2低的CRSwNP种群,需要不同的治疗途径.
更多相关视频
相关概念视频
01:23Chronic Pharyngitis
11.0K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
11.0K
01:16Drugs Used in Upper Respiratory Disorders: Overview
629
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
629