右心室节奏对成年人线粒体功能的影响
Pawut Gumrai1, Teerapat Nantsupawat1,2, Nattayaporn Apaijai2,3
1Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Physiological reports
|October 2, 2025
概括
较高的右心室节奏 (RVP) 百分比和较长的RVP持续时间与患有心脏起器和保持心脏功能的患者的细胞和线粒体氧化应激增加有关.
科学领域:
- 心脏病学 心脏病学
- 线粒体生物学 线粒体生物学
- 电力生理学 电力生理学
背景情况:
- 右心室节奏 (RVP) 与心肌病相关.
- 人类对RVP负担和线粒体功能的数据有限.
- 保持左心室缩功能是RVP研究中的关键因素.
研究的目的:
- 调查RVP负担 (持续时间和百分比) 与线粒体功能之间的关联.
- 探索PBMC中RVP暴露和氧化应激标志物之间的相关性.
- 提供关于RVP对蜂能源生产的影响的人类数据.
主要方法:
- 对96名持有永久起器器件和RVP能力的患者进行横截面研究.
- 使用外周血液单核细胞 (PBBMCS) 评估线粒体功能.
- 分析RVP百分比和心脏起器植入后的持续时间.
主要成果:
- 显著的RVP百分比 (≥40%) 独立地与细胞氧化应激增加有关 (p=0.015).
- 较长时间的RVP暴露 (≥60个月) 独立地与线粒体氧化应激增加有关 (p=0.030).
- 在调整为混变量后,这两种关联仍然显著.
结论:
- 在患有心脏起器和维护LV功能的患者中,显著的RVP百分比与细胞氧化应激增加有关.
- 长时间的RVP暴露独立地与线粒体氧化应激增加有关.
- 这些发现突显了RVP负担对细胞和线粒体健康的影响.
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