抵抗运动干预恢复功能能力,改善百岁老人的脆弱生物标志物
Diego Marcos-Perez1, Adrián Hernandez-Vicente2,3,4, Sara Cruces-Salguero1
1Cellular Oncology Group, Biodonostia (Biogipuzkoa) Health Research Institute, San Sebastián, Spain.
Journal of cachexia, sarcopenia and muscle
|October 2, 2025
概括
抵抗运动改善了百岁老人的功能能力,并减少了百岁老人的脆弱性. 这种干预也对脆弱性和炎症生物标志物产生了积极影响,为健康老龄化提供了新的见解.
科学领域:
- 老年学和运动科学
- 分子生物学与衰老的研究
背景情况:
- 百岁老人表现出异常长寿,但仍然面临生理衰退和脆弱.
- 之前的运动干预已经显示出对其他人群的虚弱有好处,但不是特别适用于百岁老人.
研究的目的:
- 评估一项为期12周的抗力运动干预对百岁老人的功能能力和脆弱性的影响.
- 描述与百岁老人虚弱和炎症相关的分子生物标志物的表达.
主要方法:
- 对12名百岁以上的人进行了为期12周的抵抗运动干预,随机分配到对照组或干预组.
- 使用短物理性能电池 (SPPB) 和物理性能和移动性检查 (PPME) 测量了功能能力.
- 使用碎的脆弱现象型和脆弱性特征尺度5 (FTS5) 评估脆弱性. 使用qRT-PCR和ELISA分析了分子生物标志物.
主要成果:
- 干预组在SPPB (p=0.01) 和PPME (p<0.001) 评分上显示出显著的改善.
- 观察到脆弱性显著减少,脆性表型 (p=0.001) 和FTS5 (p=0.05) 评分有所改善.
- 与脆弱性 (例如,miR454-3p) 和炎症 (例如,IL-6) 相关的生物标志物显示出改变的表达模式,并随着干预改善,与功能和脆弱性测量相关.
结论:
- 抵抗运动有效地提高了功能状态,并减少了百岁老人的脆弱性.
- 观察到的改善与脆弱性和炎症生物标志物的有益变化有关.
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